social determinants of health

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Unequal Cancer: Leukemia Study Finds Children In Poverty Face Earlier Relapse

How might poverty impact childhood cancer?

That’s the question pediatric oncologist Dr. Kira Bona, a researcher at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, set out to answer.

Her findings: Even with the same medical treatment, children with leukemia living in high-poverty areas were more likely to suffer an early relapse compared to their wealthier counterparts. The research, published this week in the journal Pediatric Blood & Cancer, is important, Bona says, because earlier relapses of this particular cancer — the most common pediatric cancer, called acute lymphoblastic leukemia — are harder to treat successfully.

We already know poverty is bad for your overall health. Among children, Bona says, poor kids tend to have worse underlying health, and higher rates of hospitalization, infectious disease and risk of death compared to more affluent children.

(DebMomOf3/Flickr)

(DebMomOf3/Flickr)

When it comes to cancer treatment though, for the 15,000 American children diagnosed with cancer every year, most are enrolled in clinical trials and treated using similar protocols, Bona said. Still, she said: “Historically, in pediatric oncology, we haven’t included social determinants of health, like poverty and education, as part of the data we collect in clinical trials; we’ve had an almost exclusive focus on biology.”

But since about 20 percent of kids in the U.S. live in poverty, Bona says, that non-biological data is also critical.

I spoke with Bona more about the latest research. Here, edited, is some of our discussion:

What’s the bottom-line finding here?

We looked at 10 years of data; 575 kids ages 1-18 who were treated at major academic medical centers around the U.S, with uniform therapy as part of the same two consecutive clinical trials. We went back and analyzed disease outcome data — overall survival and relapse data — with the question: Does poverty impact these disease outcomes? We used a proxy for poverty, zip codes linked to U.S. census data, to determine high-poverty or low-poverty areas.

We did not see a significant difference in overall survival between high-poverty and low-poverty groups. Additionally, we did not find a significant difference in relapse rates. But we did see a significant difference in the timing of relapse. And the timing of relapse is important, because if you experience an early relapse it’s harder for us to ultimately cure you. Continue reading

Beyond Medicine: The Road From Health Insurance To Health

By Katherine Gergen Barnett, M.D., and Lauren Taylor, MPH, M.Div

Now that as many as 6.4 million low- and middle-income Americans across 34 states have health insurance as a result of the Affordable Care Act, it’s worth asking this question: When does health insurance turn into actual health?

It’s a legitimate question because the impact of health insurance on health has been shown to be less impressive than we might wish. At least one study out of Massachusetts, for instance, has demonstrated reductions in mortality associated with insurance status, while other studies out of Oregon show only modest reductions in mental health disease burden. So how much health have we really gained nationwide from the ACA’s insurance expansion? It remains to be seen.

In the meantime, it may be time to turn our collective attention to a slightly different question: Where else in Americans’ lives might we find more substantive ways to improve health?

The Blue Cross Blue Shield of Massachusetts Foundation recently released a report which might help answer some of these questions. Researchers, led by Elizabeth H. Bradley, Ph.D., of the Yale School of Public Health, reviewed available literature on the health improvements and cost reductions associated with interventions beyond the scope of traditional medical care. The authors point to the strong evidence that increased investment in selected social services — housing support, nutritional assistance, case management for low-income families, children with asthma and seniors — as well as various models of partnership between health care and social services can offer substantial health benefits and reduce health care costs for targeted populations.

 In other words, the research demonstrates that when these interventions are targeted at high-cost, high-need patients, the results can make a huge difference in people’s lives, and also save the system money.

As a longtime primary care physician working in an urban hospital, my patients (often underserved families) confirm this empirical evidence. Here’s just one example:

The mother of a family has been coming to me for years. Her body and medical chart are riddled with multiple diagnoses: high blood pressure, chronic pain, anxiety, depression, high sugars and obesity, for which she takes numerous medications. Her life was chaotic — homeless with two young girls, a constant state of fighting in shelters, hyper vigilance for her girls’ safety and a state of depression that was only getting darker. Her girls also started getting their care through me and though they were more resilient in this state of constant flux and stress, their own lives were slowly falling apart in the long shadows of their mother’s mental illness. As a physician, it was hard to know where to start to get this family back to better health. As a mother myself and a public health advocate, I knew I had to start with the mother and her primary concerns.

And so in every visit we addressed her housing issues — filling out form after form, making calls and writing letters — alongside her other medical issues. Last year, she came in elated. She finally had secured housing. The next several visits were a flurry of pictures — new bedrooms and her smiling girls. But far beyond the pictures, there was a transformation. My patient started seeing a therapist again, taking her psychiatric medications, exercising and taking better care of her body. Her daughters also came to see me in the months that followed and it was if they were plants in the sun, finally growing back into their girlhoods. The oldest was just starting to dream about college. And though I am not naïve enough to think that their secure housing will make their health consistently good, it shifted the landscape entirely. Enough that they were able to start taking care of their lives and each other.

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