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Brain Cancer: Gene Test May Do Work Of Biopsy, Help Track Tumors

Performing a brain biopsy (Wikimedia Commons)

Performing a brain biopsy (Wikimedia Commons)

If you remember the progression of bad medical news about the late Sen. Ted Kennedy, you know that a diagnosis of brain cancer tends to go like this: Something prompts suspicion — in Kennedy’s case, a seizure. A brain scan adds more information. Then the surgeons drill through the skull for a biopsy, taking a sample of the tumor for an analysis of its make-up that then guides the medical team’s treatment strategy.

New research just out of Massachusetts General Hospital suggests a possible improvement on that routine: Instead of the brain biopsy, the researchers found, it may be possible to analyze a patient’s brain tumor just by taking a sample of cerebrospinal fluid and checking the genetic material in tiny sacs that the tumor sheds into the fluid. And that method could also enable doctors to track a tumor over time — it’s far easier to take repeated spinal fluid samples than to repeatedly drill into the skull — and thus follow how the tumor evolves and fight it as it does.

Xandra Breakefield of Mass. General’s Molecular Neurogenetics Unit explains that these latest brain-tumor findings fit into the relatively new field — from perhaps the last five years or so — of analyzing DNA and RNA in body fluids to track cancer patients’ tumors.

“Each tumor is a bit of an individual in the sense that different kinds of changes in the DNA of the cells turn it into a tumor and define the kind of tumor it is,” she said. “So in this age of personalized medicine and making drugs for cancer that target specific changes that are driving specific tumors, when a person starts having symptoms, the physician wants to know, is this a tumor and if so, what kind of a tumor is it? Is it going to be slow-growing or fast-growing? That’s going to determine how aggressively, or how, to go after it.”

Dr. Breakefield and her team found genetic evidence  in spinal fluid that a tumor was very slow-growing — good news for a patient and very important for the medical team to know. When it’s known that a tumor is less aggressive, surgery may be able to spare more of a patient’s brain, she said. Continue reading