Here’s a rare treat: potential good news about antibiotic resistance.
For years, the drumbeat of warnings has grown increasingly dire: The bugs are evolving more and more resistance to our biggest antibiotic guns. Some bacteria — strains of tuberculosis and gonorrhea among them — have even become resistant to all antibiotics. Remember the bad old days before these wonder drugs, when bacterial infections were so often death sentences? No one wants to go back there.
So today’s report in the journal Nature offers a nicely contrasting ray of antimicrobial hope: It reports the discovery in soil of a potentially powerful new antibiotic, dubbed teixobactin (pronounced takes-o-bactin), that appears to be less vulnerable to evolving resistance than other antibiotics.
“Early on, we saw that there was no resistance developed to teixobactin, and this is of course an unusual and intriguing feature of the compound,” says Northeastern professor Kim Lewis, senior author on the Nature paper. The methods used to discover and develop the compound have “a good chance of helping revive the field of antibiotic discovery,” he says.
Teixobactin worked “exceptionally well” to kill resistant bacteria in mice, Lewis says, but it will take several years and probably over $100 million to develop it into a drug that could be prescribed to human patients. It’s among two dozen other compounds that he and colleagues have turned up using a novel method to develop substances found in soil that could be useful as antibiotics.
Teixobactin works by attacking the biological building blocks of the bacteria’s cell walls, says co-author Tanja Schneider of the University of Bonn. That basic target, which is hard for the cell to modify, may help explain why the bacteria seem unable to develop resistance, she says. Continue reading